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A 4-week trial of once-weekly administration of a long-acting FGF21 analog, PF-05231023, increased systolic and diastolic blood pressure and heart rate while reducing triglycerides without changing body weight in obese human subjects with hypertriglyceridemia with or without T2D [37]

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Gradual titration is essential to minimize gastrointestinal side effects

doi: 10.1016/j.physbeh.2011.12.001 7 GautierJFChoukemSPGirardJ

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